Notably, stratification based on CD163 + /OPN + macrophage infiltration showed only a trend toward worse overall survival and recurrence-free survival in the high infiltration group, but the differences did not reach statistical significance (Supplementary Fig. 2H, I ).
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Rab37-mediated OPN secretion enriches SPP1<sup>+</sup> macrophages through autocrine-paracrine signaling to drive lung tumor progression.
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