Methylone promotes neurite outgrowth and has long-lasting effects on fear extinction learning.

Neuropsychopharmacology · 2026 · PMC12823647 · PMID 40849539

Europe PMC DOI

hedged sentences

0.3000

closest p · 6.0× alpha

0.3000

boldest claim

The sentences

did not reach statistical significancep = 0.3not close (p > 0.1)

The effect of methylone in the JHW-007 treated group did not reach statistical significance (p = 0.3, n.s.), and there was no effect of any inhibitor in the absence of methylone.

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highly significantno p-value reported

Among the most highly significant and/or down-regulated genes were dual specificity phosphatase 1 (Dusp1), FosB proto-oncogene (Fosb), early growth response protein 4 (Egr4), neuronal PAS domain protein 4 (Npas4), nuclear receptor subfamily 4 group A member 1 (Nr4a1).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.