Multimodal data-driven predictive model for vancomycin serum concentrations in postoperative cardiac surgery patients under cardiopulmonary bypass: a single-center retrospective study.

Front Pharmacol · 2025 · PMC12823941 · PMID 41585868

Europe PMC DOI

hedged sentences

0.0690

closest p · 1.4× alpha

0.0820

boldest claim

The sentences

borderline significantP = 0.069so close (0.05 < p ≤ 0.1)

CPB duration was a borderline significant risk factor (β = 0.177, OR = 1.194, 95%CI 0.996–1.462, P = 0.069).

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showed a trendP = 0.082so close (0.05 < p ≤ 0.1)

The second vancomycin dosing regimen (0.5 g q6h) showed a trend towards a protective effect compared to the conventional regimen (β = −0.646, OR = 0.524, 95%CI 0.246–1.064, P = 0.082).

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