Functional analysis of NPR2 variants supports the therapeutic rationale for CNP in short stature.

Am J Hum Genet · 2026 · PMC12824620 · PMID 41512838

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantp = 5.8 × 10 −10actually significant

This yielded a highly significant fit (Pearson’s R 2 = 0.438, p = 5.8 × 10 −10 ) and a clear relationship between reduced cGMP signaling and shorter stature.

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nominally significantp < 0.05actually significant

Variants with FDR < 0.05 in at least one source were confirmed as nominally significant ( p < 0.05) with consistent effect direction in the other available data sources.

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