Antigen binding triggers long-range conformational changes in monoclonal antibodies.

Front Immunol · 2025 · PMC12824876 · PMID 41583438

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a clear trendno p-value reported

In adalimumab, a clear trend emerges, by which most of the studied residues are more exposed in the G0 variant than in G0F, consistent with a more open Fc conformation in the afucosylated state.

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