Lack of sustained improvements in erectile function following low-intensity extracorporeal shockwave therapy correlate with decreases in corporal brain-derived neurotropic factor: a pilot study and prospective clinical trial.

Sex Med · 2025 · PMC12825299 · PMID 41583708

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approached but did not reach significanceno p-value reported

Patients with mild–moderate ED (IIEF-EF score 17-21, N = 6) initially experienced a slight fold-increase in BDNF at Study Times #2 and #3, followed by a decrease of 0.52 ± 0.18 at Time #4 and 0.42 ± 0.17 at Time #5 which approached but did not reach significance.

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did not reach statistical significanceno p-value reported

nNOS: Overall, nNOS levels increased by 1.11 ± 0.08 fold at Study Time #2, 1.08 ± 0.06 fold at Study Time #3, 1.03 ± 0.06 fold at Study Time #4, and 1.11 ± 0.08 fold at Study Time #5, though increases did not reach statistical significance ( Figure 2B ).

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