The short-term and long-term clinical outcomes from early versus delayed minimally invasive intervention for acute necrotic collections in necrotizing pancreatitis: a systematic review and meta-analysis.

A pilot randomized controlled trial (RCT) evaluating an early on-demand strategy, triggered by persistent or unresolved organ failure, showed a trend toward reduced major complications/death (20% vs. 46.7%, P = 0.25) compared with standard care, though statistical significance was not achieved [ 15 ] .

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A nonsignificant trend toward higher new-onset organ failure was observed in the early group, though only 5 of 18 included studies reported this outcome.

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