Gut microbiota, lipid metabolism, and PCOS: A Mendelian randomization and mediation analysis.

Medicine (Baltimore) · 2026 · PMC12826245 · PMID 41560095

Europe PMC DOI

hedged sentences

0.0310

closest p · 0.6× alpha

0.0310

boldest claim

The sentences

nominally significantP = .031actually significant

Among all methods and metabolites, only the weighted median estimate for GCST90277281 indicated a nominally significant association (OR = 0.93, 95% CI: 0.87–0.99, P = .031), suggesting a possible weak inverse effect.

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borderline significantno p-value reported

Additionally, the Q test result for Prevotella sp000434975 and TG (48:2) was borderline significant and merits attention (Table S8 and PDF 3, Supplemental Digital Content, https://links.lww.com/MD/R163 ; https://links.lww.com/MD/R164 ). 4.

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close to significanceno p-value reported

However, for Rhodococcus , the P -values from the Q test and MR-PRESSO were close to significance, indicating potential heterogeneity interference; thus, its results should be interpreted with caution alongside the main effect estimates.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.