Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease.

J Am Heart Assoc · 2025 · PMC12826937 · PMID 41368830

Europe PMC DOI

hedged sentences

0.0830

closest p · 1.7× alpha

0.0830

boldest claim

The sentences

borderline significantP =0.083so close (0.05 < p ≤ 0.1)

In the total population, PRS as a continuous variable was borderline significant for CAD risk (HR, 1.08 [95% CI, 0.99–1.18], P =0.083).

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did not reach statistical significanceno p-value reported

Joint Association of ePWV and ApoE ε4 Genotype With CAD in Black Individuals by Sex Further sex‐stratified analysis among Black individuals (Table S7 ) revealed that in Black women, ApoE ε4 carriers with ePWV ≥10 m/s had a relatively high CAD risk (HR, 2.25 [95% CI, 0.72–7.10], P =0.165), although the result did not reach statistical significance.

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