Impact of ALDH2 genotypes and alcohol consumption on age at first-ever ischemic stroke: A cohort study in Taiwan.

Alcohol Clin Exp Res (Hoboken) · 2026 · PMC12828095 · PMID 41324337

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hedged sentences

0.0660

closest p · 1.3× alpha

0.0660

boldest claim

The sentences

did not reach statistical significancep = 0.066so close (0.05 < p ≤ 0.1)

Although the formal ALDH2 –alcohol interaction term did not reach statistical significance in our model (Table 4 , Model 3, β = −4.81 years, 95% CI: −9.96–0.33, p = 0.066)—possibly due to the small number of ALDH2*2 carriers with heavy drinking, subgroup analyses revealed consistent and biologically plausible trends.

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borderline significantp = 0.066so close (0.05 < p ≤ 0.1)

An interaction model (Model 3) incorporating an ALDH2*2 × heavy drinking term revealed a borderline significant negative interaction effect ( β = −4.81 years, 95% CI: −9.96 to 0.33, p = 0.066), suggesting that heavy drinking might exacerbate the risk of ischemic stroke conferred by the *2 allele, leading to an earlier stroke onset.

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