HDAC6 Inhibition Reduces Seeded Tau and α-Synuclein Pathologies in Primary Neuron Cultures and Wild-Type Mice.

Moreover, α-synuclein pathology was significantly reduced in mice with preseeding ACY-738 administration, with a strong trend toward reduction after postseeding dosing.

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S3 B ; p = 0.009.) An assessment of PHF1-positive phospho-tau (pS396/pS404) in the nonseeded neurons revealed a nonsignificant trend toward reduction upon ACY-775 treatment relative to vehicle-treated cultures ( Fig. 5 D , Supplemental Materials, Fig.

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