Phosphorylated-EGFR and MMP7 upregulation in gastric cancer: Association with metastasis and poor prognosis.

Next, the stage-specific analysis of MMP7 expression in gastric adenocarcinoma revealed significantly elevated levels across all tumor grades compared with that in normal tissues (Grade 1, P=3.780×10 −2 , n=12; Grade 2, P=5.006×10 −8 , n=148; Grade 3, P=1.209×10 −10 , n=246), demonstrating progressively increasing expression from well-differentiated to poorly-differentiated tumors, although inter-grade differences did not reach statistical significance ( Fig. 2A ).

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