Genome-wide association studies in chronic venous disease: A systematic review.

24 , 36 Within the Russian population, polymorphism rs11121615, an intron variant of CAZS1, was identified as a nominally significant expression, affecting genes involved in vasculature and inflammatory response. 32 Potential therapeutic targets for VVs Protective variants against VVs identified include CRIM1, 4EBP1, MMP-10, and a missense variant in GJD3. 26 , 28 , 30 Identification of pharmacologically relevant genes among identified SNPs included KRTAP5-AS1, PLEKHA5, CBWD1, and CRIM1 in the development of VVs.

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