Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism.

Nat Commun · 2025 · PMC12830896 · PMID 41423449

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ALDOA, PGK1 , and PGAM1 showed a trend of reduction in SC-islets, while enolase ( ENO1 and ENO2 ), which directly produced PEP from upstream metabolites, were comparable between mouse- and SC-islets.

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