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MeCP2 regulates telencephalic development in human cerebral organoids.

Cell Rep · 2025 · PMC12831476 · PMID 41391149

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MUT hTAs showed a trend toward increased ventral cell proportions ( Figure 3N ; Figures S11F and S11G ), consistent with the earlier cIN overproduction noted at week 8 in hMGEOs, though cINs were underrepresented overall—presumably because they are primarily localized at the organoid’s surface and are thus the most sensitive to the single-cell dissociation process.

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