Coffin-Lowry syndrome: a systematic review of RPS6KA3 confirmed cases and implications for diagnosis and counseling.

Front Genet · 2025 · PMC12832115 · PMID 41589305

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

Although descriptive trends suggested a higher proportion of SIDEs (35%) and seizures (24%) among individuals with frameshift variants, and occasional contributions of duplications (19% to seizures, 6% to SIDEs), these did not reach statistical significance.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.