Integrated multi-omics and single-cell analysis identify SERPINE1 as a key mediator of the inflammatory tumor microenvironment in PDAC.

Genetic alterations and promoter methylation analysis of SERPINE1 Analyses of mutation profiles based on SERPINE1 expression suggested that the high SERPINE1 expression group showed slightly higher frequencies of TP53 (62%) and KRAS (61%) mutations compared with the low-expression group (53% and 60%, respectively), these differences did not reach statistical significance ( Figures 3A, B ).

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