Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging.

Bone Res · 2026 · PMC12835079 · PMID 41587965

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Lastly, COL3A1, that was found significantly upregulated in OA subchondral bone via MALDI-MSI, showed a trend (however non-significant) towards correlation with OA grade (Fig. 7c ).

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