Multidimensional predictors of fatigue in amyotrophic lateral sclerosis: a cross-sectional study in China.

These include 28 – 30 : (1) Limited healthcare accessibility, leading to delays in diagnosis, suboptimal symptom management, and inadequate access to rehabilitative services; (2) Greater economic pressure, as rural households often face lower incomes and higher out-of-pocket costs for care and transportation, compounding psychological distress; and (3) Increased social isolation, reducing opportunities for respite and emotional support, which can intensify the burden of illness.Additionally, although the lack of caregiver support did not reach statistical significance as an independent predictor in the multivariable model, its association with fatigue in univariate analysis remains relevant.

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