Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters.

Whilst maternal parity and fetal sex were not associated with any effects on either NK cell fold expansion or cytotoxicity in our study (p>0.05), there was a trend for NK cells derived from CBU collected from caesarean sections (CS-both elective and emergency, see Supplementary Figure 5 for breakdown) to achieve a higher fold expansion by day 21 of culture (72.7-fold ±37.5), compared to those isolated from CBU collected from vaginal deliveries (VD; 40.9-fold ±21.0), however this did not reach statistical significance in this cohort (p<0.07; Figure 4B ; subtypes of delivery plotted in Supplementary Figure 5A ).

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