Hemorrhagic risk of concomitant direct oral anticoagulants and fluoroquinolones: integration of pharmacovigilance and therapeutic drug monitoring.

Front Pharmacol · 2026 · PMC12835336 · PMID 41608411

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a numerical trendno p-value reported

Consistently, TDM showed significantly elevated peak dabigatran concentrations with levofloxacin (133.36 ng/mL, P = 0.008) and moxifloxacin (138.20 ng/mL, P < 0.001) compared to monotherapy (65.34 ng/mL), alongside a numerical trend towards more bleeding events.

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did not reach statistical significanceno p-value reported

The point estimate for moxifloxacin was elevated but did not reach statistical significance (adj.ROR = 2.37, 95% CI: 0.76–8.86) ( Table 2 ).

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