Metabolic signatures of the integrated profile of cardiovascular autonomic modulation and cardiorespiratory fitness in apparently healthy individuals.

Physiol Rep · 2026 · PMC12835618 · PMID 41588850

Europe PMC DOI

hedged sentences

0.0120

closest p · 0.2× alpha

0.0190

boldest claim

The sentences

approached significancep = 0.012actually significant

Age differences in females approached significance ( p = 0.012) (Table S1 ).

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marginal significancep = 0.019actually significant

Interestingly, these metabolites, together with sarcosine, which showed marginal significance in females, p = 0.019, comprise the mitochondrial arm of the choline degradation pathway, suggesting that mitochondrial disturbances may underlie unfavorable CAM‐CRF profiles.

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