Managing Bipolar Disorder With Aripiprazole Once Monthly: From Symptom Stabilization to Functional Recovery.

Psychiatry Investig · 2026 · PMC12835639 · PMID 41403199

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an increasing trendno p-value reported

These side effects can lead to medication discontinuation and an increasing trend of substituting with antipsychotic medications that have mood-stabilizing effects [ 6 ].

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did not reach statistical significancep=0.14not close (p > 0.1)

a decreasing trendno p-value reported

When the dosage of AOM was calculated in chlorpromazine-equivalent doses and combined with oral antipsychotics for patients with bipolar I disorder only, a decreasing trend was observed, though it did not reach statistical significance (p=0.14).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.