Development and internal validation of an immune-based prognostic modeling of early-onset colorectal cancer <i>via</i> machine learning.

World J Clin Oncol · 2026 · PMC12836025 · PMID 41608336

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In multivariable analysis, advanced stage remained associated with shorter PFS (HR = 2.98, 95%CI: 1.36-6.51; P = 0.012), while high CD16+CD56+NK cell percentage showed a trend toward shorter PFS; however, with no statistical significance (HR = 1.74, 95%CI: 0.67-4.55; P = 0.281; Supplementary Table 2 ).

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