Importantly, the STROKESTOP trial provided randomized evidence that systematic screening for AF in an elderly population (aged 75-76 years) with intermittent ECG monitoring was feasible and safe, and although the reduction in stroke or SE did not reach conventional statistical significance, the intervention group demonstrated a favorable trend towards improved clinical outcomes, including fewer strokes and lower mortality[ 18 ].
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Subclinical atrial fibrillation: Implications of recent trials for guideline updates?
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Although the stroke incidence was low at approximately 1% per patient-year in both groups, ischemic stroke, SE and the composite of stroke/SE were numerically lower in the edoxaban arm but did not reach statistical significance.