Efficacy of regorafenib in the treatment of advanced hepatocellular carcinoma: A systematic review and meta-analysis.

World J Gastrointest Oncol · 2026 · PMC12836161 · PMID 41607763

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failed to reach statistical significanceno p-value reported

However, confirmatory phase III trials for immunotherapies have often failed to reach statistical significance for OS endpoints[ 31 ].

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