Similar to G-CSF, which exhibited significantly higher level in O 3 -exposed TTP EpiKO mice compared with O 3 -exposed floxed controls, CXCL1/KC and CCL2/MCP-1 levels also trended higher in O 3 -exposed TTP EpiKO , although these differences did not reach statistical significance ( Fig. 4G–I ; Table S3 ).
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Tristetraprolin protects against ozone-induced acute lung injury and inflammation in mice.
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The total cell counts showed an increasing trend in the O 3 -exposed floxed control mice versus FA-exposed floxed control mice ( Fig. 4C ).