German guidelines for the diagnosis and treatment of squamous-cell carcinoma and adenocarcinoma of the esophagus-version 4.0.

363 One study showed a trend toward better OS with chemoradiotherapy in long-term follow-up (41.5 versus 56.5 months) ( n = 64 versus 76). 364 This benefit was independent of whether chemoradiotherapy was given before or after resection, although only 40% of patients were able to receive post-operative therapy according to protocol.

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With regard to progression, there was a highly significant difference between the two groups after a median follow-up period of 21 months: progression occurred in 1.5% of patients in the therapy group and in 25% in the observation group.

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