Improved sex-specific cardiovascular risk prediction with multi-omics data in people with type 2 diabetes.

Cardiovasc Diabetol · 2025 · PMC12837037 · PMID 41444601

Europe PMC DOI

hedged sentences

0.0780

closest p · 1.6× alpha

0.0780

boldest claim

The sentences

almost reached statistical significanceP = 0.078so close (0.05 < p ≤ 0.1)

0.835; ΔC-index, 0.011; P = 0.035; NRI: − 0.8%, P = 0.811; IDI: 0.001, P = 0.812), which was highly attributable to the model improvement among males, which almost reached statistical significance in C-index increase and NRI but not IDI statistics (C-index: 0.835 vs. 0.823; ΔC-index, 0.012; P = 0.078; NRI: 9.8%, P = 0.086; IDI: − 0.005, P = 0.792).

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did not reach statistical significanceno p-value reported

In women, the marginal improvements in model accuracy did not reach statistical significance in our study, which suggests that a protein-extended SCORE2-Diabetes model is sufficient for MACE risk assessment in women with T2D.

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