Complex I Modulator BI4500 Reduces MASH by Limiting Oxidative Stress and Reprogramming Lipid Metabolism via AMPK in MCD Rats.

ROS levels, expressed as the percent increase from State 4 to State 3 respiration, were reduced by CIM treatment, with a trend toward significance ( p = 0.07) compared with untreated mitochondria ( Figure 1 d).

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A similar trend was observed at the protein level for SREBP-1c in the hepatic nuclear fraction, although these changes did not reach statistical significance ( Figure 5 b).

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