Gut Microbial Composition and Short-Chain Fatty Acid Metabolism in Cognitively Unimpaired Adults Stratified by Amyloid-β Status.

Mediation Analyses (Amyloid-Stratified Causal Framework) Across 721 SCFA–taxon combinations, one species ( Clostridiales bacterium within Oscillospiraceae ) showed a nominally significant mediation of valeric acid’s relationship with Aβ status (ACME p = 0.048) ( Figure 7 ; Supplementary Table S5 ).

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