Liquid Biopsy in Clear Cell Renal Cell Carcinoma: Diagnostic Potential of Urinary miRNAs.

When considering the overall miRNA expression ( miRNA Sum ), the difference between healthy controls and ccRCC patients remained highly significant (U = 452.5, Z = −3.157, p = 0.002), confirming a distinct urinary miRNA signature associated with ccRCC ( Table 2 ).

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miR-210 showed a trend toward decrease (Z = −1.870, p = 0.061), while miR-let-7b was slightly reduced (Z = −1.964, p = 0.049).

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