Comparison of Stool Microbiome in Children with Cystic Fibrosis Treated with and Without Elexacaftor-Tezacaftor-Ivacaftor-A Pilot Study.

Int J Mol Sci · 2026 · PMC12841031 · PMID 41596463

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a negative trendno p-value reported

Alpha diversity showed a negative trend with the duration of ETI therapy for both bacteriome and mycobiome.

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a possible trendno p-value reported

Also, in unweighted UniFrac PCoA, the ETI treatment group demonstrated an intermediate position between the untreated group and the healthy control group, with a p -value of 0.067 when compared to healthy controls, indicating a possible trend toward microbial restoration with ETI treatment. 2.2.4.

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