Integrative Multi-Omics Analysis Reveals Molecular Signatures of Recurrence in Paired Primary and Recurrent High-Grade Serous Ovarian Cancer.

Although the change in IRF8 expression did not reach statistical significance, it exhibited a trend of increased expression in recurrent tissues, similar to the RNA sequencing results ( Figure 4 ).

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Our IHC analysis to validate the protein-level expression of the selected genes confirmed significant upregulation of IL7R, IRF8, and PTPRC in recurrent tumors, whereas NSG1 exhibited a decreasing trend.

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