Microenvironment Modulates Tumorigenicity of Breast Cancer Cells Depending on Hormone Receptor Status.

FABP4—a marker of mature/functional adipocytes, with prognostic relevance in cancer [ 27 ]—showed a trend toward increased expression in adjacent explants, whereas vimentin displayed an increase in both adjacent and distant explants, compared to normal explants ( Figure 1 A).

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In MCF7 cells, a decreasing trend in KLF4 expression was observed following treatment with adjacent -CM compared to normal -CM ( Figure 3 A), whereas SOX2 and Nanog levels remained unchanged with all treatments.

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In T47D cells, adjacent -CM induced an increasing trend in Nanog expression compared to control - and normal -CM ( Figure 3 B).

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