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An Altered Lipid Profile Is Indicative of Increased Insulin Requirement in Children and Adolescents at the Onset of Type 1 Diabetes.

J Pers Med · 2026 · PMC12842677 · PMID 41590507

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Considering the pubertal stage at onset, the only difference found between the prepubertal and pubertal stages was related to C-peptide values (0.43 ± 0.48 versus 0.55 ± 0.38; p < 0.03), while IR, although higher in the pubertal stage, did not reach statistical significance.

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