Profiling Serum Oxylipin Metabolites Across Melanoma Subtypes and Immunotherapy Responders.

Metabolites · 2025 · PMC12844009 · PMID 41590622

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0.0650

closest p · 1.3× alpha

0.0950

boldest claim

The sentences

showed a trendp = 0.065so close (0.05 < p ≤ 0.1)

Specifically, cutaneous melanoma patients who responded to immune checkpoint therapy showed a trend toward lower levels of baseline serum PGJ 2 than mucosal responders ( p = 0.065) ( Figure 3 e).

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a notable trendp = 0.095so close (0.05 < p ≤ 0.1)

There was a notable trend towards decreased 11β-13,14-dihydro-15-keto prostaglandin F2α in rare melanomas compared to cutaneous (H = 6.378, p = 0.095) and enrichment in 13-OxoODE in acral and mucosal melanoma (H = 6.667, p = 0.083) ( Supplementary Figure S3 .

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