Total Neoadjuvant Therapy Versus Conventional Chemoradiotherapy in Rectal Cancer: Impact on Tumor Regression Grade and the Predictive Value of CEA.

Medicina (Kaunas) · 2026 · PMC12844250 · PMID 41597512

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.2220

boldest claim

The sentences

borderline significantp = 0.070so close (0.05 < p ≤ 0.1)

In the TNT subgroup, logistic regression showed a borderline significant model, χ 2 (5) = 10.20, p = 0.070 (Nagelkerke R 2 = 0.282), correctly classifying 72.1% of cases.

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did not reach statistical significancep = 0.222not close (p > 0.1)

Subgroup Analysis: TNT Group Among patients who received total neoadjuvant therapy (TNT), the association between preoperative CEA and the pathological response followed a similar trend as the overall cohort but did not reach statistical significance ( p = 0.222, Fisher’s exact test).

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