Hydroalcoholic Extracts of <i>Cucumis prophetarum</i> L. Affect the Insulin Signaling Pathway in an In Vitro Model of Insulin-Resistant L6 Myotubes.

Regarding the phosphorylation levels of proteins involved in the insulin signaling pathway, in L6-myotubes treated with PA + CpHaR, we observed that the phosphorylation of IRS-1 at Tyr612 was not increased compared to PA-treated myotubes, whereas phosphorylation of IRS-1 at Ser307 was reduced by approximately 12%, although this decrease did not reach statistical significance ( Figure 4 D).

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