Engineering Enhanced Immunogenicity of Surface-Displayed Immunogens in a Killed Whole-Cell Genome-Reduced Bacterial Vaccine Platform Using Class I Viral Fusion Peptides.

The global correlation across all time points remained highly significant (ρ = 0.65, p < 10 −4 ).

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Although heteromeric designs exhibited a mild trend toward higher antibody titers relative to homomeric counterparts ( p = 0.0947), this difference did not reach statistical significance, suggesting that sequence heterogeneity may modestly influence B-cell engagement but remains underpowered for confirmation.

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Although exploratory analyses initially suggested higher titers in some formulations containing multiple immunomodulatory sequences, these patterns did not reach statistical significance and were not evaluated using factorial models with interaction terms.

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