Adenovector 26 Encoded RSV Prefusion F Protein (Ad26.RSV.preF) Does Not Predispose to Enhanced Respiratory Disease in Preclinical Rodent Models.

Vaccines (Basel) · 2026 · PMC12846498 · PMID 41601003

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showed a trendno p-value reported

Alveolitis scores showed a trend toward increased histopathology at higher challenge virus doses in both vaccinated and control groups ( Figure S2B ).

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failed to reach significanceno p-value reported

Histopathological analysis of lung sections of RSV B Wash-challenged animals after vaccination with 10 6 , 10 7 , or 10 8 vp Ad26.RSV.preF demonstrated significantly lower scores for the parameters assessed when compared to the FI-RSV group ( p ≤ 0.0069, Wilcoxon rank-sum test with 3-fold Bonferroni correction), except for perivasculitis, which failed to reach significance.

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