Uncovering GSTK1 and PTGER3 as biomarkers for breast cancer prognosis through comprehensive analyses.

Discov Oncol · 2025 · PMC12847519 · PMID 41432840

Europe PMC DOI

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0.1500

closest p · 3.0× alpha

0.1500

boldest claim

The sentences

did not reach statistical significancep = 0.150not close (p > 0.1)

After adjusting for TNM stage and molecular subtype in the multivariate analysis, GSTK1 remained an independent prognostic factor (HR = 0.657, 95% CI 0.473–0.913, p = 0.012), while the prognostic association of PTGER3 did not reach statistical significance (hazard ratio = 0.785, 95% confidence interval = 0.565–1.092, p = 0.150) (Fig. 6 B).

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highly significantno p-value reported

Boxplots showed that the expression of both GSTK1 and PTGER3 was significantly lower in tumor tissues compared to normal tissues, with highly significant differences (Fig. 7 A).

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