Higher local recurrence as the distinct failure pattern in early-onset rectal cancer: a tailored MRI score to guide therapy.

Kaplan–Meier analysis confirmed that these differences were highly significant ( P < 0.001 for both DFS and OS).

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Exploratory molecular analysis in a subset of patients ( N = 274) demonstrated a trend toward higher frequencies of specific alterations in the EOLARC group, although these differences did not reach statistical significance likely due to the limited sample size (Supplementary Table 1 ).

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