Cannabidiol perturbs macrophage polarization by interfering with the metabolic flux and PI3K/Akt pathway.

RT-qPCR analysis revealed that Arg1 mRNA expression was slightly elevated in the presence of CBD, however, this increase did not reach statistical significance (Fig. 5 B) and the protein of arginase-1 was not detectable by Western blot (Fig. 5 C-D).

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