Cross-ancestry comparison of aptamer and antibody protein measures.

Nat Commun · 2026 · PMC12847899 · PMID 41571639

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hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 4.07 × 10 −9actually significant

Given the large number (>1 × 10 7 ) of highly significant variants following multiple-testing correction ( p < 4.07 × 10 −9 ), we consider a Chi-Square value in or above the 75th percentile across all MESA participants as evidence of ancestry-differentiated allele frequencies.

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nominally significantno p-value reported

While the majority of the 51 proteins with a nominally significant AD-MR association on both platforms showed concordant directions of MR estimates on each platform, 5 showed opposite directions of effect between analyses with SomaScan versus Olink instruments, including PILRA (Fig. 6 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.