IL‑1 receptor antagonism attenuates renal fibrosis via RNF182‑driven MFN2 destabilization and mitochondrial dysfunction.

In accordance with our screening criteria, co-treatment with rhIL-1Ra significantly attenuated the TGF-β1-induced upregulation of RNF182 and LRRC32, while the effects on GABRA5 were variable and did not reach statistical significance under the same conditions (Fig.

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