Disposition and effects of alpha-pyrrolidinoisohexanophenone (α-PHiP) in comparison with cocaine: an observational study.

Although a slight increase in salivary cortisol was observed following administration, this change did not reach statistical significance across the study population, indicating that disposition in oral fluid occurred independently of measurable alterations in cortisol secretion dynamics. 3.4 α-PHiP urinary excretion The total amount of α-PHiP excreted in urine over the 5-h period varied considerably among individuals, ranging from approximately 0.004–0.06 mg and only about 0.11% of the intranasally administered dose was excreted unchanged in urine.

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