Visit‑to‑visit variability of inflammation-immunity indices and prognosis in hepatocellular carcinoma.

Subgroups and secondary endpoints There was no evidence of effect modification by BCLC stage (interaction p = 0.28) or HBV status (interaction p = 0.34), and only a nonsignificant trend toward stronger associations in non-curative versus curative therapy settings (interaction p = 0.12) (Table 3 ).

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When modeled categorically, the highest quartile of SII-VIM conferred a 72% higher hazard of death compared with the lowest quartile (HR 1.72, 95% CI 1.25–2.36; p = 0.001; FDR q = 0.004), with a significant trend across quartiles (p-trend < 0.001; FDR q = 0.002).

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