Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs.

The kinetics of HIL-23-induced STAT3 phosphorylation were supported by intracellular staining of pSTAT3 through a slight decline in late STAT3 phosphorylation that however did not reach statistical significance (Fig. 3 D + E).

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