MicroRNA-29a-5p contributes to neuroinflammation through TLR7.

J Neuroinflammation · 2026 · PMC12849500 · PMID 41514337

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did not reach statistical significanceno p-value reported

At baseline, miR-29a-5p expression in APP/PS1 mice appeared lower than in WT, but this difference did not reach statistical significance (Fig.

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a slight trendno p-value reported

Pre-treatment with an LNA-based miR-29a-5p inhibitor prior to miR-29a-5p administration showed a slight trend towards preventing neuronal loss induced by miR-29a-5p alone in both APP/PS1 and WT mice, however, this effect was not statistically significant.

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